Bacterial polysaccharides are unique due to their higher purity, hydrophilic nature, and a finer three-dimensional fibrous structure. Primarily, these
polymers provide protection, support, and energy to the microorganism, however, more recently several auxiliary properties of these
biopolymers have been unmasked. Microbial
polysaccharides have shown therapeutic abilities against various illnesses, augmented the healing abilities of the herbal and Western medicines, improved overall health of the host, and have exerted positive impact on the growth of gut dwelling beneficial bacteria. Specifically, the review is discussing the mechanism through which
bacterial polysaccharides exert anti-inflammatory,
antioxidant, anti-
cancer, and anti-microbial properties. In addition, they are holding promising application in the 3D printing. The review is also discussing a perspective about the metagenome-based screening of
polysaccharides, their integration with other cutting-edge tools, and synthetic microbiome base intervention of
polysaccharides as a strategy for
prebiotic intervention. This review has collected interesting information about the
bacterial polysaccharides from Google Scholar, PubMed, Scopus, and Web of Science databases. Up to our knowledge, this is the first of its kind review article that is summarizing therapeutic,
prebiotics, and commercial application of
bacterial polysaccharides.