[Elastolytic activity in eye tissues and serum antiproteases in corneal burns].

Abstract

Within the first week after deep thermic burns of rabbit cornea elastolytic activity was increased in the impaired zone of cornea, in the cornea zones surrounding the burns as well as in ciliary body, iris of the eye and in chamber humor, whereas the antitryptic activity was increased in eye tissues. Both elastolytic and antitryptic activities were decreased within two weeks after the burns. In circulating blood alterations in content of alpha 1-antitrypsin and alpha 2-macroglobulin were directed against the proteolytic enzymes, which were activated after the cornea burns. Instillation of the antiprotease drug hordox within the first ten days after the burns led to a decrease in the elastolytic activity detected in the cornea zone with burns as well as to more favourable development of postburn inflammation.

• Authors: N B Chesnokova, N E Sosulina
• Journal: Voprosy meditsinskoi khimii (Vopr Med Khim) 1986 Jul-Aug Vol. 32 Issue 4 Pg. 110-3 ISSN: 0042-8809 [Print] Russia (Federation)
• Vernacular Title: Elastoliticheskaia aktivnost' v tkaniakh glaza i syvorotochnye antiproteazy pri ozhoge rogovitsy.
• PMID: 3639670 (Publication Type: English Abstract, Journal Article)

Chemical References

• Protease Inhibitors
• Pancreatic Elastase

Topics

• Animals
• Corneal Injuries
• Eye Burns (blood, enzymology)
• Pancreatic Elastase (antagonists & inhibitors)
• Protease Inhibitors (blood)
• Rabbits