Abstract | OBJECTIVE: METHODS: The database of a tertiary medical center was retrospectively searched for consecutive patients who underwent total thyroidectomy for PTC in 2011-2020 with ultrasound follow-up after 1 year. Changes in ultrasound features of the major salivary glands were compared between patients treated or not treated with RAI postoperatively. RESULTS: The cohort included 158 patients, of whom 109 (69%) were treated postoperatively with RAI (mean dose, 131 mCi) and 49 were not (control group). Sonographic changes were observed in the major salivary glands in 43% of the study group and 18% of the control group (p = 0.002), including coarse echotexture, decreased echogenicity, fibrosis, and atrophy. Higher RAI doses were significantly correlated with the prevalence and severity of glandular changes (p < 0.0001). CONCLUSION: RAI treatment following thyroidectomy is associated with a dose-response effect and adverse changes in the major salivary glands and should be prescribed carefully. LEVEL OF EVIDENCE:
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Authors | Nir Tsur, Gal Avishai, Uri Alkan, Roy Hod, Thomas Shpitzer, Eden Bitton, Hanna Gilat |
Journal | The Laryngoscope
(Laryngoscope)
Vol. 133
Issue 5
Pg. 1271-1275
(05 2023)
ISSN: 1531-4995 [Electronic] United States |
PMID | 36354236
(Publication Type: Journal Article)
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Copyright | © 2022 The American Laryngological, Rhinological and Otological Society, Inc. |
Chemical References |
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Topics |
- Humans
- Thyroid Neoplasms
(diagnostic imaging, radiotherapy, surgery)
- Iodine Radioisotopes
(adverse effects)
- Retrospective Studies
- Salivary Glands
(diagnostic imaging)
- Thyroid Cancer, Papillary
(diagnostic imaging, radiotherapy, surgery)
- Thyroidectomy
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