Reduction in snoring with phosphocholinamin, a long-acting tissue-lubricating agent.

• Abstract: The efficacy of a long-acting lubricating and coating agent, phosphocholinamin, in reducing snoring was tested in 12 persons, six of whom received the agent as nose drops and six of whom received a placebo (tap water nose drops). In all subjects, the noise level was measured continuously by using a microphone taped near the cricothyroid notch. In the group treated with phosphocholinamin, the maximum nocturnal decibel level was reduced by a mean +/- SD of 13 +/- 3%, and the snoring index (defined as the number of snores per hour of sleep) was reduced by 25 +/- 12%. In the group treated with placebo, the maximum nocturnal decibel level increased 9 +/- 22% and the snoring index increased 1 +/- 20%. The differences between the two groups were statistically significant (P less than .05). It is concluded that phosphocholinamin can provide a useful medical alternative in the treatment of snoring and that further trials of this agent are indicated.
• Authors: V Hoffstein, S Mateiko, S Halko, R Taylor
• Journal: American journal of otolaryngology (Am J Otolaryngol) 1987 Jul-Aug Vol. 8 Issue 4 Pg. 236-40 ISSN: 0196-0709 [Print] UNITED STATES
• PMID: 3631421 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Drug Combinations
• Phosphatidylcholines
• phosphocholinamin
• Oxygen
• Mineral Oil

Topics

• Administration, Intranasal
• Adult
• Aged
• Airway Resistance (drug effects)
• Drug Combinations (therapeutic use)
• Female
• Humans
• Male
• Middle Aged
• Mineral Oil (therapeutic use)
• Oxygen (blood)
• Phosphatidylcholines (therapeutic use)
• Sleep Apnea Syndromes (drug therapy)
• Snoring (drug therapy)