Facilitation of ECT by caffeine pretreatment.

Abstract

In this study, eight patients participated in a standardized protocol to assess the effects of caffeine on seizures in ECT. Caffeine sodium benzoate (500-2000 mg) was administered intravenously 10 minutes before ECT, and seizure duration was compared with that of a previous treatment unmodified by caffeine. Seizure duration was significantly increased during ECTs preceded by caffeine. Three other patients given caffeine when seizures of adequate duration could no longer be elicited at maximal stimulus levels experienced longer seizures. Administration of caffeine was not associated with significant cardiovascular or other (including cognitive) adverse effects.

• Authors: B Shapira, B Lerer, D Gilboa, H Drexler, S Kugelmass, A Calev
• Journal: The American journal of psychiatry (Am J Psychiatry) Vol. 144 Issue 9 Pg. 1199-202 (Sep 1987) ISSN: 0002-953X [Print] United States
• PMID: 3631318 (Publication Type: Journal Article)

Chemical References

• Benzoates
• Drug Combinations
• Caffeine
• caffeine, sodium benzoate drug combination

Topics

• Benzoates (administration & dosage, adverse effects, pharmacology)
• Blood Pressure (drug effects)
• Brain (drug effects)
• Caffeine (administration & dosage, adverse effects, pharmacology)
• Depressive Disorder (therapy)
• Drug Combinations (administration & dosage, adverse effects, pharmacology)
• Electroconvulsive Therapy (methods)
• Electroencephalography
• Female
• Heart Rate (drug effects)
• Humans
• Male
• Middle Aged
• Orientation (drug effects)
• Pulse (drug effects)