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The effects of exifone, a new agent for senile memory disorder, on two models of memory in the mouse.

Abstract
The effects of exifone (ADLONE), hexahydro-2,3,4,3',4',5'-benzophenone, were tested in two models of memory in the mouse: habituation of exploratory activity and antagonism of amnesia induced by scopolamine in a passive avoidance task. In the first model, mice which had received exifone (128 and 256 mg/kg IP) 30 minutes before a 3 minute exposure to a staircase exploratory test showed a more marked decrease in exploratory activity in the same apparatus 24 hours later (habituation) than a control group indicating improved memory. Similar results were obtained with piracetam (512 mg/kg, IP). In the second model exifone (512 mg/kg PO), administered 60 minutes before both the learning and retention trials of a standard step-through passive avoidance, task partially antagonized the amnesia induced by 10 mg/kg scopolamine IP administered immediately after the learning trial. Similar results were obtained with piracetam (800 mg/kg PO). Taken together these results suggest that exifone facilitates memory function in simple rodent models in a manner consistent with its supposed therapeutic effects in man.
AuthorsR D Porsolt, A Lenègre, I Avril, L Stéru, G Doumont
JournalPharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 27 Issue 2 Pg. 253-6 (Jun 1987) ISSN: 0091-3057 [Print] United States
PMID3628440 (Publication Type: Journal Article)
Chemical References
  • Benzophenones
  • exifone
  • Scopolamine
  • Piracetam
Topics
  • Amnesia (chemically induced, drug therapy)
  • Animals
  • Avoidance Learning (drug effects)
  • Benzophenones (pharmacology, therapeutic use)
  • Dementia (drug therapy)
  • Exploratory Behavior (drug effects)
  • Habituation, Psychophysiologic (drug effects)
  • Male
  • Memory (drug effects)
  • Mice
  • Mice, Inbred Strains
  • Models, Biological
  • Piracetam (pharmacology)
  • Scopolamine (pharmacology)

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