Abstract |
The effects of exifone ( ADLONE), hexahydro-2,3,4,3',4',5'-benzophenone, were tested in two models of memory in the mouse: habituation of exploratory activity and antagonism of amnesia induced by scopolamine in a passive avoidance task. In the first model, mice which had received exifone (128 and 256 mg/kg IP) 30 minutes before a 3 minute exposure to a staircase exploratory test showed a more marked decrease in exploratory activity in the same apparatus 24 hours later (habituation) than a control group indicating improved memory. Similar results were obtained with piracetam (512 mg/kg, IP). In the second model exifone (512 mg/kg PO), administered 60 minutes before both the learning and retention trials of a standard step-through passive avoidance, task partially antagonized the amnesia induced by 10 mg/kg scopolamine IP administered immediately after the learning trial. Similar results were obtained with piracetam (800 mg/kg PO). Taken together these results suggest that exifone facilitates memory function in simple rodent models in a manner consistent with its supposed therapeutic effects in man.
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Authors | R D Porsolt, A Lenègre, I Avril, L Stéru, G Doumont |
Journal | Pharmacology, biochemistry, and behavior
(Pharmacol Biochem Behav)
Vol. 27
Issue 2
Pg. 253-6
(Jun 1987)
ISSN: 0091-3057 [Print] United States |
PMID | 3628440
(Publication Type: Journal Article)
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Chemical References |
- Benzophenones
- exifone
- Scopolamine
- Piracetam
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Topics |
- Amnesia
(chemically induced, drug therapy)
- Animals
- Avoidance Learning
(drug effects)
- Benzophenones
(pharmacology, therapeutic use)
- Dementia
(drug therapy)
- Exploratory Behavior
(drug effects)
- Habituation, Psychophysiologic
(drug effects)
- Male
- Memory
(drug effects)
- Mice
- Mice, Inbred Strains
- Models, Biological
- Piracetam
(pharmacology)
- Scopolamine
(pharmacology)
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