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[Medium- and long-term clinical study on the use of the new non-steroidal anti-inflammatory drug flunoxaprofen in osteoarthrosis].

Abstract
The efficacy and the tolerability of the new non-steroidal antiinflammatory agent flunoxaprofen was assessed in the long-lasting management of pain and joint motility impairment of 28 patients suffering from radiologically proven osteoarthritis localized on the large joints (hip and knee). The patients were treated with flunoxaprofen 200-400 mg/day per os for 2 months (18 patients) or for 4 months (10 patients) and the following variables were assessed: spontaneous diurnal and nocturnal pain, pain on passive motion, pain on active motion with or without load, quality of sleep, joint motion range, intercondylar and intermalleolar straddles and gluteus-heel straddle; patients' and physician' evaluation of flunoxaprofen efficacy. Moreover a number of clinical and laboratory controls were carried out to study the tolerability of the drug (arterial blood pressure, heart rate, hepatic and renal function tests, haematological examination). The assessments were made before the starting of the treatment and at 15-day intervals thereafter. The results show that all variables for pain intensity greatly and progressively improved during flunoxaprofen treatment; the quality of sleep as well as the joint motion range improvement went along the progressive decrease in pain intensity. None of the clinical and laboratory parameters studied showed any modification during flunoxaprofen treatment. No side-effects were observed in any patients, either after 4 months treatment or using 400 mg/die. It is concluded that flunoxaprofen may be considered an effective and safe non-steroidal antiinflammatory agent in the long-lasting management of pain and joint motility impairment of osteoarthritic patients.
AuthorsM Capone, F Martinelli
JournalMinerva medica (Minerva Med) Vol. 78 Issue 16 Pg. 1219-25 (Aug 31 1987) ISSN: 0026-4806 [Print] Italy
Vernacular TitleStudio clinico a medio e lungo termine sull'uso del nuovo antiinfiammatorio non steroideo flunoxaprofene nell'osteoartrosi.
PMID3627532 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Anti-Inflammatory Agents, Non-Steroidal
  • Benzoxazoles
  • flunoxaprofen
Topics
  • Aged
  • Aged, 80 and over
  • Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, therapeutic use)
  • Benzoxazoles (administration & dosage, therapeutic use)
  • Drug Administration Schedule
  • Female
  • Follow-Up Studies
  • Hip Joint
  • Humans
  • Knee Joint
  • Male
  • Middle Aged
  • Osteoarthritis (drug therapy)

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