Progression of chronic renal failure in patients given ketoacids following amino acids.

Abstract

Twelve patients with chronic renal failure who exhibited a progressive decline in 24-hour creatinine clearance, despite being given for 2 to 10 months a diet containing 0.3 g per kg ideal weight of protein and 7 to 9 g mg per kg ideal weight of phosphorus, supplemented with vitamins, CaCO3, and 10 g per day of essential amino acids, were changed to a supplement containing predominantly ketoacids. In six patients whose serum creatinine was 7.5 mg/dl or greater at changeover, progression continued unabated. In six patients with serum creatinine levels at changeover of 6.6 to 7.4 mg/dl, one was non-compliant with the diet and progressed to dialysis. In the other five, progression, measured as the rate of change of a bimonthly radioisotope clearance, has been undetectable during the ensuing one to two years. There has been no change in urea appearance, blood pressure, phosphaturia or proteinuria. Nutrition has been maintained. Thus this ketoacid supplemented regimen apparently halted the progression of moderately-severe chronic renal failure for at least a year in a small group of patients in whom restriction of protein and phosphate intake without ketoacids failed to halt progression. In more severe renal failure, no effect on progression was seen.

• Authors: M Walser, N D LaFrance, L Ward, M A VanDuyn
• Journal: Kidney international (Kidney Int) Vol. 32 Issue 1 Pg. 123-8 (Jul 1987) ISSN: 0085-2538 [Print] United States
• PMID: 3626295 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Amino Acids, Essential
• Keto Acids
• Creatinine

Topics

• Adult
• Aged
• Amino Acids, Essential (administration & dosage)
• Blood Pressure
• Creatinine (metabolism)
• Female
• Glomerular Filtration Rate
• Humans
• Keto Acids (therapeutic use)
• Kidney Failure, Chronic (therapy)
• Male
• Middle Aged
• Patient Compliance
• Proteinuria (therapy)