Abstract |
The association between platelet counts and mechanical ventilation was assessed in 61 newborn infants with respiratory distress syndrome, 10 infants with congenital diaphragmatic hernia, and 10 infants with tracheoesophageal fistula. A significant decrease in platelet counts was observed during mechanical ventilation: (mean +/- SD) reduction of 39% +/- 5%, 42% +/- 5.6%, and 11.9% +/- 5.4% in the three groups, respectively, independent of other causes. In the group with congenital diaphragmatic hernia, there was a significant correlation between mean airway pressure and the reduction in platelet counts. In a subsequent series of experiments, platelet counts were recorded before and during ventilation in rabbits. A significant mean decrease of 37.3% in platelet counts was associated with ventilation with either air or pure oxygen. Results of these studies indicate that mechanical ventilation itself may cause a major decrease in platelet count in newborn infants.
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Authors | A Ballin, G Koren, D Kohelet, R Burger, M Greenwald, A C Bryan, A Zipursky |
Journal | The Journal of pediatrics
(J Pediatr)
Vol. 111
Issue 3
Pg. 445-9
(Sep 1987)
ISSN: 0022-3476 [Print] United States |
PMID | 3625416
(Publication Type: Comparative Study, Journal Article)
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Topics |
- Animals
- Female
- Hernias, Diaphragmatic, Congenital
- Humans
- Infant, Newborn
- Male
- Platelet Count
- Rabbits
- Respiration, Artificial
(adverse effects)
- Respiratory Distress Syndrome, Newborn
(therapy)
- Retrospective Studies
- Thrombocytopenia
(etiology)
- Tracheoesophageal Fistula
(therapy)
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