Abstract | Background: Methods: We conducted a retrospective analysis of patients with resectable stage II-IV colon cancer who were treated with oxaliplatin and capecitabine at our institution from January 2016 to December 2017. Laboratory tests and computed tomographic (CT) data before, during and up to 18 months after the end of chemotherapy were extracted. Spleen volume was determined by volumetric measurements. Splenomegaly was defined as an over 30% increase in spleen volume from baseline. Results: Out of 144 patients, 102 patients (70.8%) developed splenomegaly, and 75 (73.5%) recovered at 18 months after the end of chemotherapy. Higher cumulative dose intensity of oxaliplatin (P=0.001) and higher baseline platelet count (P=0.045) were risk factors associated with splenomegaly. Compared to those without splenomegaly, splenomegaly patients experienced more severe reduction in platelet (P<0.001), erythrocyte (P=0.010), neutrophil (P=0.002) and lymphocyte (P=0.006) counts and were more likely to undergo dose reductions of oxaliplatin (21.6% vs. 7.1%, P=0.038) as well as interruptions of chemotherapy (18.6% vs. 4.8%, P=0.040) due to thrombocytopenia. Conclusions:
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Authors | Ruoyu Ji, Guanghua Huang, Jing Xu, Xiaoduo Yu, Aiping Zhou, Chunxia Du |
Journal | Translational cancer research
(Transl Cancer Res)
Vol. 11
Issue 7
Pg. 1880-1888
(Jul 2022)
ISSN: 2219-6803 [Electronic] China |
PMID | 36249886
(Publication Type: Journal Article)
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Copyright | 2022 Translational Cancer Research. All rights reserved. |