Accumulation of ceroid in smooth muscle indicates severe malabsorption and vitamin E deficiency.

Abstract

Four patients had accumulation of ceroid in smooth muscle (lipofuscinosis), which indicated severe or uncontrolled malabsorption, with confirmed vitamin E deficiency in three cases. The distribution of the pigment was systematic, and there seemed to be an association between malabsorption syndrome and vitamin E deficiency. Vitamin E supplementation seems to be indicated in such patients, and it is suggested that studies of smooth muscle function should be made in cases of heavy accumulation of ceroid.

• Authors: G W Stamp, D J Evans
• Journal: Journal of clinical pathology (J Clin Pathol) Vol. 40 Issue 7 Pg. 798-802 (Jul 1987) ISSN: 0021-9746 [Print] England
• PMID: 3624501 (Publication Type: Case Reports, Journal Article)

Chemical References

• Ceroid
• Pigments, Biological

Topics

• Adult
• Aged
• Ceroid (metabolism)
• Esophagus (pathology)
• Humans
• Jejunum (pathology)
• Malabsorption Syndromes (diagnosis, pathology)
• Male
• Middle Aged
• Muscle, Smooth (metabolism, pathology)
• Pigments, Biological (metabolism)
• Vitamin E Deficiency (diagnosis, pathology)