Elimination of 16-acetyl-gitoxin in patients suffering from impaired liver function.

Abstract

In ten patients suffering from moderate to severe disturbances of liver function (hepatic cirrhosis, carcinomatous metastases of the liver) the elimination of 16-acetyl-gitoxin from plasma was measured after a single oral dose of 1.2 mg pengitoxin. In 9 of 10 patients the mean half-life amounted to 67.3 h (SD 14.2 h). In one patient with carcinomatous infiltration of the liver and concomitant cirrhosis, the half-life was prolonged to 165.3 h. The results point to an unchanged elimination of 16-acetyl-gitoxin in patients suffering from liver cirrhosis.

• Authors: K O Haustein, H Sensing, M Wesser
• Journal: International journal of clinical pharmacology, therapy, and toxicology (Int J Clin Pharmacol Ther Toxicol) Vol. 25 Issue 7 Pg. 379-81 (Jul 1987) ISSN: 0174-4879 [Print] Germany
• PMID: 3623742 (Publication Type: Journal Article)

Chemical References

• Acetyldigoxins
• pentaacetylgitoxin
• 16-acetylgitoxin
• Digoxin

Topics

• Acetyldigoxins (blood, metabolism)
• Adult
• Aged
• Biotransformation
• Digoxin (analogs & derivatives)
• Half-Life
• Humans
• Liver Diseases (blood)
• Middle Aged