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Comparison of the protective effects by human and bovine superoxide dismutase against ischemia- and reperfusion-induced impairment of kidney function in anesthetized rats.

Abstract
In a rat model of ischemia- and reperfusion-induced kidney damage, the protective effects of human superoxide dismutase produced by genetic technology (hum-SOD) were compared to those of bovine superoxide dismutase (bov-SOD). The intravenous infusion of hum-SOD and bov-SOD, started concomitantly with the kidney reperfusion after a 60-min (or 30-min) period of ischemia, significantly improved the renal function (inulin and p-amino-hippuric acid clearance rates) as compared to the vehicle-treated control group. In contrast, inactive apoenzyme of superoxide dismutase (Apo-SOD) did not improve the impaired renal function after the kidney reperfusion. Therefore, the kidney protection by hum-SOD and bov-SOD may reasonably be ascribed to their specific enzymatic function--scavenging of oxygen radicals. In this respect, hum-SOD proved to be as effective as bov-SOD. To our knowledge this is the first report on a direct pharmacologic comparison of superoxide dismutases from natural and recombinant origin.
AuthorsJ Schneider, E Friderichs, H Giertz
JournalFree radical biology & medicine (Free Radic Biol Med) Vol. 3 Issue 1 Pg. 21-6 ( 1987) ISSN: 0891-5849 [Print] United States
PMID3623186 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Apoenzymes
  • Free Radicals
  • Inulin
  • Superoxide Dismutase
  • Oxygen
  • p-Aminohippuric Acid
Topics
  • Animals
  • Apoenzymes (pharmacology)
  • Cattle
  • Free Radicals
  • Humans
  • Inulin (metabolism)
  • Ischemia (drug therapy, metabolism)
  • Kidney (blood supply, drug effects, metabolism)
  • Male
  • Oxygen (metabolism)
  • Rats
  • Rats, Inbred Strains
  • Superoxide Dismutase (pharmacology)
  • p-Aminohippuric Acid (metabolism)

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