Abstract |
In a rat model of ischemia- and reperfusion-induced kidney damage, the protective effects of human superoxide dismutase produced by genetic technology (hum-SOD) were compared to those of bovine superoxide dismutase (bov-SOD). The intravenous infusion of hum-SOD and bov-SOD, started concomitantly with the kidney reperfusion after a 60-min (or 30-min) period of ischemia, significantly improved the renal function ( inulin and p-amino- hippuric acid clearance rates) as compared to the vehicle-treated control group. In contrast, inactive apoenzyme of superoxide dismutase (Apo-SOD) did not improve the impaired renal function after the kidney reperfusion. Therefore, the kidney protection by hum-SOD and bov-SOD may reasonably be ascribed to their specific enzymatic function--scavenging of oxygen radicals. In this respect, hum-SOD proved to be as effective as bov-SOD. To our knowledge this is the first report on a direct pharmacologic comparison of superoxide dismutases from natural and recombinant origin.
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Authors | J Schneider, E Friderichs, H Giertz |
Journal | Free radical biology & medicine
(Free Radic Biol Med)
Vol. 3
Issue 1
Pg. 21-6
( 1987)
ISSN: 0891-5849 [Print] United States |
PMID | 3623186
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Apoenzymes
- Free Radicals
- Inulin
- Superoxide Dismutase
- Oxygen
- p-Aminohippuric Acid
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Topics |
- Animals
- Apoenzymes
(pharmacology)
- Cattle
- Free Radicals
- Humans
- Inulin
(metabolism)
- Ischemia
(drug therapy, metabolism)
- Kidney
(blood supply, drug effects, metabolism)
- Male
- Oxygen
(metabolism)
- Rats
- Rats, Inbred Strains
- Superoxide Dismutase
(pharmacology)
- p-Aminohippuric Acid
(metabolism)
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