Selective interactions of verapamil with anthraquinones in adriamycin-sensitive and -resistant murine and human tumour cell lines in vitro.

Abstract

Enhancement of the cytotoxicity of adriamycin (ADR) by addition of verpamil (VPM) was selective and, in part, concentration-dependent. In an ADR-resistant murine L5178Y lymphoma subline sensitivity was improved with ADR and 1 microM VPM, whereas the cytotoxic effects of mitoxantrone or esorubicin were not affected by VPM. In human ovarian SK-OV-3 tumour cells ADR cytotoxicity was only enhanced by 6.6 microM VPM and there was no selective advantage against an ADR-resistant subline. Circumvention of ADR resistance by VPM is not a universal phenomenon, appearing least effective against sublines expressing relatively low orders of resistance, which may be those most commonly encountered clinically.

• Authors: E M Gibby, O Boyse, B T Hill
• Journal: Cancer chemotherapy and pharmacology (Cancer Chemother Pharmacol) Vol. 20 Issue 1 Pg. 5-7 ( 1987) ISSN: 0344-5704 [Print] Germany
• PMID: 3621454 (Publication Type: Journal Article)

Chemical References

• Doxorubicin
• Mitoxantrone
• Verapamil
• esorubicin

Topics

• Cell Survival (drug effects)
• Colony-Forming Units Assay
• Doxorubicin (analogs & derivatives, toxicity)
• Drug Interactions
• Female
• Humans
• Mitoxantrone (therapeutic use, toxicity)
• Ovarian Neoplasms
• Verapamil (toxicity)