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[Hepatotropic action of benzobamil in CCl4 poisoning].

Abstract
The administration of an antiepileptic drug--benzobamilum-to rats with CCl4-induced hepatitis prevents the development of liver parenchyma necrosis, promotes the retention of normal enzyme activity in hepatocytes, stimulates the excretory and antitoxic liver functions. The drug has antioxidant properties, inhibits the production of lysophosphatidylcholine and the reduction in phosphatidylcholine content in the liver homogenates but fails to intensify CCl4-induced steatosis.
AuthorsA I Vengerovskiĭ, I M Sedykh, A S Saratikov
JournalBiulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 104 Issue 8 Pg. 192-5 (Aug 1987) ISSN: 0365-9615 [Print] Russia (Federation)
Vernacular TitleGepatotropnoe deĭstvie benzobamila pri intoksikatsii CCl4.
PMID3620680 (Publication Type: English Abstract, Journal Article)
Chemical References
  • benzobamil
  • Pentobarbital
Topics
  • Animals
  • Carbon Tetrachloride Poisoning (blood, drug therapy, physiopathology)
  • Liver (drug effects, physiopathology)
  • Male
  • Pentobarbital (analogs & derivatives, therapeutic use)
  • Rats

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