Abstract |
The antiarrhythmic activities of AN-132, 3-(diisopropylaminoethylamino)-2',6'-dimethylpropionanilide X 2H3PO4, compared with three reference drugs, were examined in several arrhythmic models of rats, guinea-pigs and dogs. When compared on a weight basis, AN-132 given in oral or i.v. route proved to be more potent and longer-acting than disopyramide, propaphenone and mexiletine against supraventricular and ventricular arrhythmias induced by chloroform, aconitine, ouabain and halothane- adrenaline.
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Authors | K Sakai, T Yamazaki, M Takagi |
Journal | The Tohoku journal of experimental medicine
(Tohoku J Exp Med)
Vol. 151
Issue 4
Pg. 443-51
(Apr 1987)
ISSN: 0040-8727 [Print] Japan |
PMID | 3617055
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- 3-(diisopropylaminoethylamino)-2',6'-dimethylpropionanilide, diphosphoric acid
- Anilides
- Anti-Arrhythmia Agents
- Ethylenediamines
- Mexiletine
- Ouabain
- Propafenone
- Chloroform
- Disopyramide
- Halothane
- Aconitine
- Epinephrine
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Topics |
- Aconitine
- Anilides
(therapeutic use)
- Animals
- Anti-Arrhythmia Agents
(therapeutic use)
- Arrhythmias, Cardiac
(chemically induced, drug therapy)
- Chloroform
- Disopyramide
(therapeutic use)
- Dogs
- Epinephrine
- Ethylenediamines
(therapeutic use)
- Female
- Guinea Pigs
- Halothane
- Male
- Mexiletine
(therapeutic use)
- Ouabain
- Propafenone
(therapeutic use)
- Rats
- Rats, Inbred Strains
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