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Antiarrhythmic effects of a novel diamine derivative, AN-132, on several animal models of cardiac arrhythmias.

Abstract
The antiarrhythmic activities of AN-132, 3-(diisopropylaminoethylamino)-2',6'-dimethylpropionanilide X 2H3PO4, compared with three reference drugs, were examined in several arrhythmic models of rats, guinea-pigs and dogs. When compared on a weight basis, AN-132 given in oral or i.v. route proved to be more potent and longer-acting than disopyramide, propaphenone and mexiletine against supraventricular and ventricular arrhythmias induced by chloroform, aconitine, ouabain and halothane-adrenaline.
AuthorsK Sakai, T Yamazaki, M Takagi
JournalThe Tohoku journal of experimental medicine (Tohoku J Exp Med) Vol. 151 Issue 4 Pg. 443-51 (Apr 1987) ISSN: 0040-8727 [Print] Japan
PMID3617055 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • 3-(diisopropylaminoethylamino)-2',6'-dimethylpropionanilide, diphosphoric acid
  • Anilides
  • Anti-Arrhythmia Agents
  • Ethylenediamines
  • Mexiletine
  • Ouabain
  • Propafenone
  • Chloroform
  • Disopyramide
  • Halothane
  • Aconitine
  • Epinephrine
Topics
  • Aconitine
  • Anilides (therapeutic use)
  • Animals
  • Anti-Arrhythmia Agents (therapeutic use)
  • Arrhythmias, Cardiac (chemically induced, drug therapy)
  • Chloroform
  • Disopyramide (therapeutic use)
  • Dogs
  • Epinephrine
  • Ethylenediamines (therapeutic use)
  • Female
  • Guinea Pigs
  • Halothane
  • Male
  • Mexiletine (therapeutic use)
  • Ouabain
  • Propafenone (therapeutic use)
  • Rats
  • Rats, Inbred Strains

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