Abstract | OBJECTIVE: METHODS AND ANALYSIS: We used best-corrected visual acuity (BCVA), central retinal thickness with spectral domain optical coherence photography, optical intensity ratio (OIR) with imageJ software and retinal vessel diameter with fundus photography as indicators. Data were analysed using Tukey's multiple comparisons, Wilcoxon test or Spearman's correlation analysis as appropriate. RESULTS: BCVA was significantly improved at 1 month and 3 months after the initial visit (from 2.18±0.60 to 1.54±0.84 and 1.53±0.88, p=0.030 and p=0.027, respectively). The ratio of retinal vein diameter to optic disc diameter increased in the first month (from 0.40%±0.13% to 0.52%±0.16%, p=0.005). In addition, the OIR at the initial visit was significantly correlated with BCVA at 3 months (p=0.006, r=0.58). No severe adverse effects were observed. CONCLUSION: The results showed that visual acuity and retinal vein constriction improved after lipo-PGE1 therapy. In addition, the OIR in the initial phase can be an indicator of visual prognosis after treatment with PGE1 in patients with CRAO.
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Authors | Takafumi Suzuki, Ryo Obata, Tatsuya Inoue, Yoshiki Ueta, Keiko Azuma, Hideo Tate, Kohdai Kitamoto, Chisato Otaki, Yoshihiro Hashimoto, Makoto Aihara, Naoko Tachi |
Journal | BMJ open ophthalmology
(BMJ Open Ophthalmol)
Vol. 7
Issue 1
(05 2022)
ISSN: 2397-3269 [Electronic] England |
PMID | 36161847
(Publication Type: Journal Article)
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Copyright | © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
Chemical References |
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Topics |
- Alprostadil
(therapeutic use)
- Humans
- Retina
(diagnostic imaging)
- Retinal Artery Occlusion
(drug therapy)
- Retinal Vessels
(diagnostic imaging)
- Visual Acuity
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