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[Clinical long-term studies on cefuzoname in patients with complicated urinary tract infections].

Abstract
Cefuzoname (CZON), a new semisynthetic cephalospolin antibiotic, was administered intravenously at a dose of 1.0 g twice a day for 14 days to 20 patients with complicated urinary tract infections and the therapeutic efficacy of the drug and safety were evaluated. The results obtained were summarized as follows: 1. After 5 days, clinical results were excellent in 7, moderate in 3 and poor in 9 cases. The overall effectiveness rate was 52.6%. Bacteriologically, 24 out of 32 isolated strains were susceptible to this drug, but 8 strains were found to be resistant. 2. After treatment, clinical results were excellent in 6, moderate in 3 and poor in 10 cases. The overall effectiveness was 47.4%. In bacteriological results of 32 isolated strains, 26 strains were eradicated and 6 strains persisted. 3. Among 20 cases treated none showed subjective or objective symptoms of side effects. Noted as clinical laboratory test abnormalities were eosinophilia in 1 case after 5 days, increase of S-GOT, gamma-GTP, and K in 1 case, and increase of S-creatinine in 1 case at the termination of treatment. All of these abnormalities were mild and normal values were restored soon after at the termination of the treatment.
AuthorsN Nakano
JournalThe Japanese journal of antibiotics (Jpn J Antibiot) Vol. 40 Issue 4 Pg. 907-23 (Apr 1987) ISSN: 0368-2781 [Print] Japan
PMID3613098 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Cephalosporins
  • cefuzonam
  • Ceftizoxime
Topics
  • Adult
  • Aged
  • Bacteria (drug effects, isolation & purification)
  • Ceftizoxime (analogs & derivatives)
  • Cephalosporins (administration & dosage, adverse effects, pharmacology)
  • Drug Resistance, Microbial
  • Female
  • Humans
  • Infusions, Intravenous
  • Male
  • Middle Aged
  • Urinary Tract Infections (drug therapy, microbiology)

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