Echiumin E, an Aryl Dihydronaphthalene Lignan from the Australian Invasive Plant Paterson's Curse (Echium plantagineum).

Abstract

A new aryl dihydronaphthalene lignan, echiumin E (1), and four known compounds, echiumin A, globoidnan A, (-)-rabdosiin, and rosmarinic acid (2-5), were isolated from the Australian invasive plant Echium plantagineum (Paterson's curse) for the first time. Echiumin E (1) was characterized by 1D/2D NMR spectroscopy and MS spectrometry, with its absolute configuration assigned through comparison of experimental and TDDFT-calculated ECD data. Echiumin E (1) along with compounds 3-5 were screened in vitro against three cancer cell lines (SH-SY5Y, HeLa, and PC-3) and a prostate stromal (normal) cell line (WPMY-1) using a resazurin reduction assay. Echiumin E (1) was found to be active toward HeLa cells (IC50 0.21 μM).

• Authors: Ju Jin, Darren C Holland, Anthony R Carroll, Matthew Zunk
• Journal: Journal of natural products (J Nat Prod) Vol. 85 Issue 10 Pg. 2474-2479 (10 28 2022) ISSN: 1520-6025 [Electronic] United States
• PMID: 36126331 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Lignans

Topics

• Male
• Humans
• Echium (chemistry, metabolism)
• HeLa Cells
• Australia
• Neuroblastoma
• Lignans (pharmacology, metabolism)
• Plants