[Dissociation of the anti-amnesic and antihypoxic effects of nootropic and antihypoxic preparations].

Abstract

In experimental studies on mice it was shown that piracetam, Cleregil, centrophenoxine, pyritinol possessed the most pronounced anti-amnestic activity. A close effect was noted with Euclidan, 3-hydroxypyridine and ionol. GABAergic agents (sodium oxybutyrate, phenibut, pantogam), gutimine, nicotinoyl-GABA eliminated amnesia to a lesser extent. The antihypoxic effect on the model of hypobaric hypoxia was exerted by typical antihypoxic agents (gutimine, sodium oxybutyrate, 3-hydroxypyridine). The antihypoxic activity of nootropic drugs (centrophenoxine, pyritinol, phenibut) could be determined only at a significant increase of doses. No interrelationship and the presence of dissociation in manifestation of anti-amnestic and antihypoxic effects were revealed.

• Authors: T A Voronina, T L Garibova, I V Khromova, U M Tilekeeva
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1987 May-Jun Vol. 50 Issue 3 Pg. 21-4 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Dissotsiatsiia antiamnesticheskogo i protivogipoksicheskogo éffektov u nootropnykh i protivogipoksicheskikh preparatov.
• PMID: 3609269 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antioxidants
• Psychotropic Drugs

Topics

• Amnesia (drug therapy)
• Animals
• Antioxidants (therapeutic use)
• Conditioning, Classical (drug effects)
• Drug Evaluation, Preclinical
• Electroshock
• Escape Reaction (drug effects)
• Hypoxia (drug therapy)
• Male
• Mice
• Psychotropic Drugs (therapeutic use)
• Structure-Activity Relationship