Comparative trial of amitriptyline-N-oxide and amitriptyline in the treatment of out-patients with depressive syndromes.

Abstract

Amitriptyline-N-oxide and amitriptyline were compared double-blind in a material of out-patients with depressive syndromes, 21 and 22 patients respectively. Both drugs had a good antidepressant effect. The globally rated effect was equal. The effect upon the various depressive symptoms was equal. Definite reversal of depression occurred somewhat earlier on amitriptyline-N-oxide on which side effects were also less marked, but those of an anticholinergic and of a sedative nature. No orthostatic reaction, nor any effect upon blood status or liver function was observed. Amitriptyline-N-oxide appears to show a tendency to a somewhat more rapid onset of effect and less side effects.

• Authors: W Rapp
• Journal: Acta psychiatrica Scandinavica (Acta Psychiatr Scand) Vol. 58 Issue 3 Pg. 245-55 (Sep 1978) ISSN: 0001-690X [Print] United States
• PMID: 360779 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Amitriptyline

Topics

• Adult
• Aged
• Ambulatory Care
• Amitriptyline (administration & dosage, adverse effects, therapeutic use)
• Blood Pressure (drug effects)
• Clinical Trials as Topic
• Depression (drug therapy)
• Double-Blind Method
• Drug Evaluation
• Female
• Humans
• Male
• Middle Aged
• Pulse (drug effects)
• Time Factors