Treatment of paramyotonia congenita with acetazolamide.

Abstract

Treatment of paramyotonia congenita with acetazolamide has been shown to reduce myotonic symptoms but severe weakness has developed in some patients leading to a recommendation not to use the drug in this disorder. We studied a patient with the characteristic clinical and electrophysiological profile of paramyotonia congenita. Myotonia was effectively treated with a very low dose of acetazolamide and no weakness developed. We conclude that acetazolamide can be a safe and effective medication in paramyotonia congenita.

• Authors: T J Benstead, P R Camfield, D B King
• Journal: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques (Can J Neurol Sci) Vol. 14 Issue 2 Pg. 156-8 (May 1987) ISSN: 0317-1671 [Print] England
• PMID: 3607618 (Publication Type: Case Reports, Journal Article)

Chemical References

• Acetazolamide

Topics

• Acetazolamide (therapeutic use)
• Adult
• Cold Temperature
• Dose-Response Relationship, Drug
• Electromyography
• Female
• Humans
• Myotonia Congenita (drug therapy, physiopathology)