Analogues of pyrimidine base precursors as antiphytoviral agents.

Abstract

Dihydroorotic acid hydrazide (DHOH) did not inhibit the replication of potatovirus X (PVX) in leaf disks of Nicotiana tabacum 'Samsun'. In contrast, 5-fluoroorotic acid (5-FOA) completely inhibited the replication of PVX, as demonstrated by a serological virus assay as well as a local lesion bioassay using Gomphrena globosa as the test plant. The corresponding base analogue 5-fluorouracil (5-FU) had only a weak inhibitory effect. Time-course inhibition experiments in synchronized virus-infected leaf disks led us to conclude that 5-FOA, as well as 5-azadihydrouracil (5-ADHU), an uracil catabolite analogue, inhibit the same early event in virus infection. Neither 5-FOA nor 5-ADHU had a direct inactivating effect on free PVX virions.

• Authors: G Schuster, C Arenhövel, E Golovinsky
• Journal: Antiviral research (Antiviral Res) Vol. 7 Issue 3 Pg. 179-84 (Mar 1987) ISSN: 0166-3542 [Print] Netherlands
• PMID: 3606085 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• Triazines
• dioxohexahydrotriazine
• Thiouracil
• Orotic Acid
• dihydroorotic acid hydrazide
• 5-fluoroorotic acid
• Cycloheximide
• Fluorouracil

Topics

• Antiviral Agents (pharmacology)
• Cycloheximide (pharmacology)
• Fluorouracil (pharmacology)
• Orotic Acid (analogs & derivatives, pharmacology)
• Plant Viruses (drug effects, physiology)
• Thiouracil (pharmacology)
• Triazines (pharmacology)
• Virus Replication (drug effects)