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In vitro activity of paldimycin (U-70138F) against gram-positive bacteria isolated from patients with cancer.

Abstract
The in vitro activity of paldimycin, a novel antimicrobial agent, was compared with that of vancomycin against 306 gram-positive isolates (representing 12 bacterial species) obtained from patients with cancer. Paldimycin had lower MICs for 90% of isolates than vancomycin did against most isolates tested. Its activity, however, was medium and pH dependent, being greatest in Nutrient broth at a pH of 6.8.
AuthorsK V Rolston, B LeBlanc, D H Ho, G P Bodey
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 31 Issue 4 Pg. 650-2 (Apr 1987) ISSN: 0066-4804 [Print] United States
PMID3606069 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Disaccharides
  • Glycopeptides
  • Vancomycin
  • paldimycin
  • Acetylcysteine
Topics
  • Acetylcysteine (analogs & derivatives)
  • Bacterial Infections (etiology, microbiology)
  • Disaccharides
  • Glycopeptides (pharmacology)
  • Gram-Positive Bacteria (drug effects, isolation & purification)
  • Neoplasms (complications)
  • Vancomycin (pharmacology)

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