Abstract |
The in vitro activity of paldimycin, a novel antimicrobial agent, was compared with that of vancomycin against 306 gram-positive isolates (representing 12 bacterial species) obtained from patients with cancer. Paldimycin had lower MICs for 90% of isolates than vancomycin did against most isolates tested. Its activity, however, was medium and pH dependent, being greatest in Nutrient broth at a pH of 6.8.
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Authors | K V Rolston, B LeBlanc, D H Ho, G P Bodey |
Journal | Antimicrobial agents and chemotherapy
(Antimicrob Agents Chemother)
Vol. 31
Issue 4
Pg. 650-2
(Apr 1987)
ISSN: 0066-4804 [Print] United States |
PMID | 3606069
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Disaccharides
- Glycopeptides
- Vancomycin
- paldimycin
- Acetylcysteine
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Topics |
- Acetylcysteine
(analogs & derivatives)
- Bacterial Infections
(etiology, microbiology)
- Disaccharides
- Glycopeptides
(pharmacology)
- Gram-Positive Bacteria
(drug effects, isolation & purification)
- Neoplasms
(complications)
- Vancomycin
(pharmacology)
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