Pleural decortication and hyperthermic intrathoracic chemotherapy for pseudomyxoma.

Abstract

Aim: Pleural dissemination of pseudomyxoma peritonei (PMP) is an extremely rare diagnosis, for which no standard therapy is available.Methods: We describe the successful treatment of a 67-year-old male diagnosed with left-sided intrapleural dissemination of PMP (low-grade appendiceal mucinous neoplasm), 2 years after treatment of abdominal PMP with cytoreductive surgery (CRS) and hyperthermic intra-peritoneal chemotherapy. Treatment consisted of extended pleural decortication (ePD) and oxaliplatin-based hyperthermic intrathoracic chemotherapy (HITHOC). The patient is doing well without complications or signs of recurrence, 26 months after thoracic surgery.Conclusion: ePD in combination with HITHOC is a valuable treatment for thoracic PMP.

• Authors: Viktor Proesmans, Tom Vandaele, Jan Van Slambrouck, Albert Wolthuis, André D Hoore, Jeroen Dekervel, Eric Van Cutsem, Raphaëla Dresen, Gert De Hertogh, Karlien Degezelle, Dirk Van Raemdonck, Philippe Nafteux, Laurens J Ceulemans
• Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group (Int J Hyperthermia) Vol. 39 Issue 1 Pg. 1153-1157 ( 2022) ISSN: 1464-5157 [Electronic] England
• PMID: 36049823 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Aged
• Appendiceal Neoplasms (therapy)
• Combined Modality Therapy
• Cytoreduction Surgical Procedures
• Humans
• Hyperthermia, Induced
• Male
• Peritoneal Neoplasms (diagnostic imaging, drug therapy, surgery)
• Pseudomyxoma Peritonei (diagnostic imaging, drug therapy, surgery)
• Retrospective Studies