Mechanism analysis of octapeptide from microalgae, Isochrysis zhanjiangensis for suppressing vascular injury and angiogenesis in human umbilical vein endothelial cell.

Abstract

Incorporating microalgae active peptides into functional foods is one of the hottest topics in algae research. Ile-Ile-Ala-Val-Glu-Ala-Gly-Cys (IEC) is a novel octapeptide isolated from the microalgae, Isochrysis Zhanjiangensis that inhibits the vascular injury, angiogenesis and has a protective effect on cardiovascular diseases. In this study, IEC can suppress ROS production and inhibit pro-inflammatory factors through the Nrf2/SOD/HO-1 and NF-κB signaling pathways. Additionally, IEC inhibits angiogenesis by reducing the expression of MMP2 and MMP9 via the PI3K/AKT, NF-κB, and MAPK pathways. Molecular docking also demonstrated that IEC possesses an excellent docking effect with SOD, Bcl-2 and VEGFR-2. In conclusion, this study not only provides a new idea for the prevention of cardiovascular diseases, but also proves the possibility of octapeptide (IEC) in functional food and drugs, and further improves the use value of microalgae (Isochrysis Zhanjiangensis).

• Authors: Liyuan Lin, Yuan-Lin He, Yanfei Tang, Pengzhi Hong, Chunxia Zhou, Shengli Sun, Zhong-Ji Qian
• Journal: International immunopharmacology (Int Immunopharmacol) Vol. 111 Pg. 109149 (Oct 2022) ISSN: 1878-1705 [Electronic] Netherlands
• PMID: 36027851 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 Elsevier B.V. All rights reserved.

Chemical References

• NF-kappa B
• Superoxide Dismutase

Topics

• Cardiovascular Diseases
• Haptophyta (metabolism)
• Human Umbilical Vein Endothelial Cells
• Humans
• Microalgae (metabolism)
• Molecular Docking Simulation
• NF-kappa B (metabolism)
• Phosphatidylinositol 3-Kinases (metabolism)
• Superoxide Dismutase
• Vascular System Injuries