Chronobiology and its implications for pharmacotherapy of endogenous depression.

Abstract

An open pilot study on 30 in-patients with endogenous depression showed a clear-cut circadian fluctuation of the therapeutical effect of single doses of lofepramine administered at three different times of the day (8 a.m., and 12 p.m.). A single-dose drug schedule with 210 mg lofepramine at 12 p.m. also proved superior (p less than .05) to the conventional divided-dose drug schedule with 70 mg lofepramine at three times of the day. The chronobiological background and the therapeutical consequences of these findings are discussed.

• Authors: M Philipp, A Marneros
• Journal: Pharmakopsychiatrie, Neuro-Psychopharmakologie (Pharmakopsychiatr Neuropsychopharmakol) Vol. 11 Issue 5 Pg. 235-40 (Sep 1978) ISSN: 0031-7098 [Print] Germany
• PMID: 360248 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Lofepramine

Topics

• Adult
• Circadian Rhythm
• Clinical Trials as Topic
• Depression (drug therapy, physiopathology)
• Drug Administration Schedule
• Female
• Humans
• Lofepramine (administration & dosage, therapeutic use)
• Male
• Middle Aged
• Psychiatric Status Rating Scales
• Time Factors