Pharmacokinetics and effects of isoxicam on renal function in patients with renal insufficiency.

Abstract

The pharmacokinetics of isoxicam, a new non-steroidal anti-inflammatory drug, were studied in 20 osteoarthritis patients with varying degrees of renal insufficiency. A wide variation in pharmacokinetic parameters was seen between individuals but there was no suggestion that renal function influenced pharmacokinetics. Steady state plasma isoxicam concentrations varied from 20 micrograms/ml to 130 micrograms/ml, while the plasma half-life varied from 23 hours to 58 hours. Despite a reduction in urinary prostaglandin E2 excretion, isoxicam administration did not alter renal function over a 4-week period.

• Authors: P M Brooks, M McCredie, M Prowse, M Podgorski, M Forrest, I Munro, J Boutagy, L Pei-Ling
• Journal: Pharmatherapeutica (Pharmatherapeutica) Vol. 4 Issue 10 Pg. 665-72 ( 1986) ISSN: 0308-051X [Print] England
• PMID: 3602018 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Piroxicam
• isoxicam

Topics

• Aged
• Anti-Inflammatory Agents, Non-Steroidal (adverse effects, metabolism)
• Female
• Humans
• Kidney (drug effects, physiopathology)
• Kidney Diseases (metabolism)
• Kinetics
• Male
• Middle Aged
• Piroxicam (adverse effects, analogs & derivatives, metabolism)