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Chromosomal aberrations in cultured human lymphocytes treated with aldicarb, a carbamate pesticide.

Abstract
Aldicarb was tested for its ability to induce chromosomal aberrations in human peripheral lymphocytes in vitro, in the presence of an exogenous metabolic activation system. The pesticide induced an increase in the number of chromatid and chromosome breaks. The increase was higher in the presence of S9 mix. A positive linear association between frequencies of abnormal cells and dose of aldicarb was observed.
AuthorsM González Cid, E Matos
JournalMutation research (Mutat Res) Vol. 191 Issue 2 Pg. 99-103 (Jun 1987) ISSN: 0027-5107 [Print] Netherlands
PMID3600695 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Insecticides
  • Aldicarb
Topics
  • Aldicarb (pharmacology)
  • Animals
  • Cells, Cultured
  • Chromosome Aberrations
  • Humans
  • Insecticides (pharmacology)
  • Lymphocytes (drug effects, ultrastructure)
  • Male
  • Rats
  • Rats, Inbred Strains

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