Cephalotaxine-type and homoerythrina-type alkaloids with antiproliferative effects from Cephalotaxus fortunei.

Abstract

Twenty-two cephalotaxine-type and ten homoerythrina-type alkaloids, including seven previously undescribed ones, were isolated from the twigs and leaves and the seed kernels of Cephalotaxus fortunei. Their structures were established by spectroscopic analysis, single crystal X-ray diffraction, and ECD calculation methods. Cephalofortunine A β-N-oxide (1) is the first nitrogen-oxidized homoerythrina-type alkaloid. The isolated compounds were evaluated for their in vitro antiproliferative effects against two human leukemia cell lines (THP-1 and K562). All compounds showed different levels of antiproliferation in THP-1 and K562 cells with GI50 values of 0.24-29.55 μM. Hainanensine (31) was the most active against two cancer cell lines with GI50 values of 0.24 ± 0.07, and 0.29 ± 0.01 μM, respectively.

• Authors: Chun-Xue Zhao, Hui Liu, Xin Zhang, Meng-Yue Yang, Yue-Tong Wang, Yi-Jia Xing, Jun-Xin Hua, Qin Zhang, Da-Hong Li, Jiao Bai, Yong-Kui Jing, Hui-Ming Hua
• Journal: Organic & biomolecular chemistry (Org Biomol Chem) Vol. 20 Issue 35 Pg. 7076-7084 (09 14 2022) ISSN: 1477-0539 [Electronic] England
• PMID: 36004441 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Alkaloids
• Antineoplastic Agents, Phytogenic
• Homoharringtonine

Topics

• Alkaloids (chemistry)
• Antineoplastic Agents, Phytogenic (chemistry, pharmacology)
• Cephalotaxus (chemistry)
• Homoharringtonine
• Humans
• Molecular Structure
• Plant Leaves (chemistry)