Disposition of tilidine in a fatal poisoning in man.

Abstract

A fatal intoxication due to the ingestion of tilidine, a narcotic analgesic, in conjunction with ethanol, is described. Tilidine and its two active metabolites, nortilidine and bisnortilidine, were identified and quantitated in the biological fluids and tissues by thin-layer chromatography (TLC), gas-liquid chromatography with sensitive nitrogen-phosphorus detection (GLC/NPD) and gas-liquid chromatography with mass spectrometric detection (GC/MS). The toxicological results are compared with previously reported 14C-tilidine tissue distributions in rats following oral administration and limited tissue data in a previously reported human fatality. In the present case, the death was attributed to the combined central nervous system-depressing effects of ethanol and tilidine.

• Authors: J Cordonnier, M Van den Heede, A Heyndrickx, R Wennig
• Journal: Journal of analytical toxicology (J Anal Toxicol) 1987 May-Jun Vol. 11 Issue 3 Pg. 105-9 ISSN: 0146-4760 [Print] England
• PMID: 3599916 (Publication Type: Journal Article)

Chemical References

• Cyclohexanecarboxylic Acids
• Ethanol
• Tilidine

Topics

• Adult
• Chromatography, Gas
• Chromatography, Thin Layer
• Cyclohexanecarboxylic Acids (poisoning)
• Drug Synergism
• Ethanol (adverse effects)
• Humans
• Male
• Tilidine (metabolism, poisoning)