Abstract |
As part of a study on the structure-activity relationship of antitumor-active tropolone derivatives, a series of bistropone analogues, related to potently active bistropolone 1a, were synthesized and tested for their antitumor activity in in vitro (KB cell) and in vivo ( leukemia P388 in mice) systems. The methoxytropones 3 and 5, hydroxytropothione 10, and (N-methylamino)tropones 12 and 13 were inactive in both systems. Methoxytropone 6 exhibited weak activity, whose potency was equal to that of monotropolone 2a.
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Authors | M Yamato, K Hashigaki, J Sakai, Y Takeuchi, S Tsukagoshi, T Tashiro, T Tsuruo |
Journal | Journal of medicinal chemistry
(J Med Chem)
Vol. 30
Issue 7
Pg. 1245-8
(Jul 1987)
ISSN: 0022-2623 [Print] United States |
PMID | 3599030
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Cycloheptanes
- Tropolone
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Topics |
- Animals
- Antineoplastic Agents
(chemical synthesis, pharmacology)
- Cycloheptanes
(chemical synthesis)
- Mice
- Structure-Activity Relationship
- Tropolone
(chemical synthesis, pharmacology)
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