Inflammatory markers of hemogram parameters as predictive factors for disease severity in anti-N-methyl-D-aspartate receptor encephalitis.

Abstract

OBJECTIVE:

This study aimed to investigate the utility of inflammatory markers of hemogram parameters as objective indicators of disease severity in anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis.

METHODS:

A total of 98 patients were retrospectively reviewed. Inflammatory markers of hemogram parameters, including neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), and platelet-lymphocyte ratio, were acquired within 24 h of admission. We then analyzed their utility as predictive factors for disease severity at different time points assessing with the modified Rankin Scale (mRS).

RESULTS:

There were 49 patients in the mild group (mRS ≤ 2) and 49 patients in the moderate-to-severe (mRS > 2) group at admission. The moderate-to-severe group presented more frequently with psychiatric symptoms and central hypoventilation, as well as a lower lymphocyte count, a higher neutrophil count, a higher NLR and a higher MLR (all p < 0.05) when compared with the mild group. NLR and MLR showed similar positive correlations with mRS scores (r = 0.40, r = 0.40, both p < 0.001). Further multivariate logistic regression analyses indicated that NLR > 4.232 was an independent risk factor for moderate-to-severe status at admission. Meanwhile, NLR and MLR were associated with disease severity at different stages of follow-up but showed no independent predictive value.

CONCLUSION:

Our findings suggested that NLR was an independent risk factor for moderate-to-severe status in the initial stage of anti-NMDAR encephalitis with a cut-off value of > 4.232.

• Authors: Yin-Xi Zhang, Jia-Li Pu, Meng-Ting Cai, Qing-Qing Tao, Jun Tian, Chun-Hong Shen, Yong-Feng Xu, Bao-Rong Zhang
• Journal: Multiple sclerosis and related disorders (Mult Scler Relat Disord) Vol. 67 Pg. 104078 (Nov 2022) ISSN: 2211-0356 [Electronic] Netherlands
• PMID: 35985211 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 Elsevier B.V. All rights reserved.

Chemical References

• Biomarkers

Topics

• Humans
• Anti-N-Methyl-D-Aspartate Receptor Encephalitis (complications, diagnosis)
• Retrospective Studies
• Lymphocytes
• Neutrophils
• Biomarkers
• Severity of Illness Index
• Prognosis