[Studies on the significance of 17 alpha,20 alpha-dihydroxy-4-pregnen-3-one (17 alpha,20 alpha-P) in pregnancy induced hypertension (PIH) and its site of production].

Abstract

We have measured 17 alpha,20 alpha-P, 17 alpha-OHP and aldosterone in maternal peripheral blood, umbilical arterial and venous blood in normal pregnancy and PIH. The PIH cases studies had a systolic blood pressure above 140 mmHg and a diastolic blood pressure above 90 mmHg for more than two weeks. The 800 G supernatant of the ovary and placenta from human was used as an enzyme source for in vitro studies. Incubation was carried out in a Dubnoff-type incubator at 37 degrees C for 2, 4, 8 and 12 hours. As substrates, [4-14C]-P5,[4-14C]-P and [4-14C]-17 alpha-OHP were used. Concentrations of aldosterone and 17 alpha-OHP of PIH cases were not significantly different from those of control. Concentrations of 17 alpha,20 alpha-P in normal pregnancy and PIH were as follows. Peripheral vein blood, 0.39 +/- 0.08 and 0.64 +/- 0.19 ng/ml, umbilical arterial blood, 0.33 +/- 0.09 and 0.65 +/- 0.19 ng/ml, umbilical vein blood 0.50 +/- 0.12 and 0.84 +/- 0.17 ng/ml, respectively. The 17 alpha,20 alpha-P levels in the maternal peripheral venous, umbilical arterial and venous blood of hypertensive cases were all higher than those of the normal pregnancy. The synthesis of 17 alpha,20 alpha-P in vitro occurred from all the substrates used in the ovary and only from [4-14C]17 alpha-OHP in the placenta. These results suggest that 17 alpha,20 alpha-P is somehow related to the increase in blood pressure and the amount of this steroid is significantly greater in PIH cases than controls.(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: K Satoh
• Journal: Nihon Sanka Fujinka Gakkai zasshi (Nihon Sanka Fujinka Gakkai Zasshi) Vol. 39 Issue 5 Pg. 731-8 (May 1987) ISSN: 0300-9165 [Print] Japan
• PMID: 3598269 (Publication Type: English Abstract, Journal Article)

Chemical References

• Hydroxyprogesterones
• 17,20-dihydroxy-4-pregnen-3-one
• Aldosterone

Topics

• Aldosterone (blood)
• Female
• Fetal Blood (analysis)
• Humans
• Hydroxyprogesterones (biosynthesis, blood, metabolism)
• Hypertension (blood)
• In Vitro Techniques
• Infant, Newborn
• Ovary (metabolism)
• Placenta (metabolism)
• Postpartum Period
• Pregnancy
• Pregnancy Complications, Cardiovascular (blood)