Effect of a combination of altrenogest and double PGF2α administrations on farrowing variation, piglet performance and colostrum IgG.

Abstract

The variation of gestation length in sows leads to difficulties performing farrowing supervision. The present study was performed to investigate whether oral administration of altrenogest until 112 days of gestation and double administration of PGF2α at 113 days of gestation can synchronise the onset of parturition in sows and minimise deleterious effects on the incidence of stillbirths and colostrum quality. Additionally, the effects of synchronised farrowing on colostrum yield and piglet birth weight, colostrum intake and survival rate of piglets until seven days of postnatal life were also investigated. In total, 193 Landrace x Yorkshire crossbred sows were randomly allocated according to parity number into two groups, i.e. control (n = 95) and treatment (n = 98). The control sows were allowed to farrow naturally. The treatment sows were orally administered 20 mg per day of altrenogest for four days from 109 to 112 days of gestation and were administered PGF2α twice on day 113 of gestation. Individual body weight at birth and 24 h after birth of piglets in all litters were determined in both control (n = 1609) and treatment (n = 1707) groups. Colostrum consumption of all piglets, colostrum yield, colostrum IgG and serum progesterone of sows were determined. On average, the total number of piglets born per litter were 17.0 ± 3.1. The proportion of sows farrowed before 114 days of gestation was higher in the control than the treatment group (8.4% and 2.0%, respectively, P = 0.05) and 92.8% of sows in the treatment group farrowed on day 114 of gestation. The percentage of stillborn piglets per litter did not differ significantly between control and treatment groups (4.5% and 4.6%, respectively). Colostrum yield of sows did not differ between control and treatment groups (5.52 ± 0.13 and 5.28 ± 0.12 kg, respectively, P = 0.174). However, colostrum intake of piglets was lower in the treatment than the control group (354.7 ± 6.6 and 381.2 ± 7.0 g, respectively, P = 0.012). Colostrum IgG was higher in the control than the treatment group (41.2 ± 1.1 and 37.3 mg per ml, P = 0.013). In conclusion, altrenogest treatment from 109 to 112 days and double administrations of PGF2α on day 113 of gestation can control gestation length in sows. No deleterious effects of this protocol on the incidence of stillbirths and sow colostrum yield were detected. However, piglet colostrum intake and colostrum IgG were compromised. Thus, care of newborn piglets in the treatment group should be considered.

• Authors: Preechaphon Taechamaeteekul, Natchanon Dumniem, Alisa Pramul, Junpen Suwimonteerabutr, Kridtasak Sang-Gassanee, Padet Tummaruk
• Journal: Theriogenology (Theriogenology) Vol. 191 Pg. 122-131 (Oct 01 2022) ISSN: 1879-3231 [Electronic] United States
• PMID: 35981411 (Publication Type: Journal Article, Randomized Controlled Trial, Veterinary)
• Copyright: Copyright © 2022 Elsevier Inc. All rights reserved.

Chemical References

• Immunoglobulin G
• altrenogest
• Dinoprost
• Trenbolone Acetate

Topics

• Animals
• Colostrum
• Dinoprost
• Female
• Immunoglobulin G
• Lactation
• Pregnancy
• Stillbirth (veterinary)
• Swine
• Swine Diseases
• Trenbolone Acetate (analogs & derivatives)