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Studies on phytohemagglutinin-induced peritonitis of mice: dynamics of inflammatory responses and influence of anticomplementary agents and anti-inflammatory drugs.

Abstract
The intraperitoneal injection of phytohemagglutinin in the mouse resulted in the marked accumulation of leukocytes, especially macrophages, in the peritoneal cavity between 8 and 36 h after the injection. Parallel to the accumulation of macrophages, exudation of plasma proteins into the peritoneal cavity was observed. When the effect of anticomplementary agents (FUT-175 and K-76 COONa) and anti-inflammatory drugs (indomethacin and dexamethasone) on phytohemagglutinin-induced peritonitis was examined, FUT-175, K-76 COONa and indomethacin suppressed only the plasma protein exudation. On the other hand, dexamethasone suppressed both the accumulation of macrophages and the plasma protein exudation.
AuthorsI Nagaoka, Y Ishibashi, T Yamashita
JournalInternational journal of tissue reactions (Int J Tissue React) Vol. 9 Issue 3 Pg. 179-88 ( 1987) ISSN: 0250-0868 [Print] Switzerland
PMID3596959 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Benzamidines
  • Blood Proteins
  • Complement Inactivator Proteins
  • Guanidines
  • Phytohemagglutinins
  • Sesquiterpenes
  • K 76 carboxylic acid
  • Dexamethasone
  • Indomethacin
  • nafamostat
Topics
  • Animals
  • Anti-Inflammatory Agents (therapeutic use)
  • Benzamidines
  • Blood Proteins (analysis)
  • Complement Inactivator Proteins (therapeutic use)
  • Dexamethasone (therapeutic use)
  • Exudates and Transudates (analysis)
  • Guanidines (therapeutic use)
  • Indomethacin (therapeutic use)
  • Male
  • Mice
  • Mice, Inbred Strains
  • Peritonitis (chemically induced)
  • Phytohemagglutinins
  • Sesquiterpenes (therapeutic use)

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