HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effects of cisapride on gastric and esophageal emptying in progressive systemic sclerosis.

Abstract
The effects of cisapride on gastric emptying, esophageal emptying, and gastrointestinal symptoms were evaluated in 8 patients with progressive systemic sclerosis who had delayed gastric emptying of the solid or liquid component of a meal, or both. A double-isotope technique was used to measure gastric emptying, and esophageal emptying was measured as the time for a bolus of the solid meal to enter the stomach. Gastrointestinal symptoms were assessed by a questionnaire. On 2 days each patient received cisapride (10 mg) or placebo intravenously, 5 min before an esophageal and gastric emptying test. After these 2 days each subject took cisapride (10 mg q.i.d., p.o.) for 1 mo. Cisapride improved solid and liquid gastric emptying (p less than 0.001), but had no significant effect on esophageal emptying (p less than 0.1). Upper gastrointestinal symptoms were reduced after cisapride (p less than 0.001), and no side effects were reported. These results indicate that gastroparesis is a treatable cause of morbidity in progressive systemic sclerosis.
AuthorsM Horowitz, G J Maddern, A Maddox, J Wishart, B E Chatterton, D J Shearman
JournalGastroenterology (Gastroenterology) Vol. 93 Issue 2 Pg. 311-5 (Aug 1987) ISSN: 0016-5085 [Print] United States
PMID3596167 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Piperidines
  • Cisapride
Topics
  • Adult
  • Cisapride
  • Esophagus (drug effects)
  • Female
  • Gastric Emptying (drug effects)
  • Gastrointestinal Diseases (drug therapy)
  • Humans
  • Male
  • Middle Aged
  • Peristalsis (drug effects)
  • Piperidines (therapeutic use)
  • Scleroderma, Systemic (drug therapy, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: