Contact allergy to the active ingredients of Kathon CG.

Abstract

The preservative Kathon CG is a commercial preparation, consisting of 2 active ingredients and other components. 28 patients with contact allergy to Kathon CG participated in a study in which patch testing was performed with serial dilutions, and with 5 chromatographically separated fractions. All reacted to fraction IV, and 2 patients also to fraction II. Mass spectrometry and nuclear magnetic resonance spectrometry identified fraction II and IV to be the active ingredients; 2-methyl-4-isothiazolin-3-one and 5-chloro-2-methyl-4-isothiazolin-3-one.

• Authors: M Bruze, I Dahlquist, S Fregert, B Gruvberger, K Persson
• Journal: Contact dermatitis (Contact Dermatitis) Vol. 16 Issue 4 Pg. 183-8 (Apr 1987) ISSN: 0105-1873 [Print] England
• PMID: 3595116 (Publication Type: Journal Article)

Chemical References

• Pharmaceutic Aids
• Preservatives, Pharmaceutical
• Thiazoles
• 2-methyl-4-isothiazolin-3-one
• Kathon 886
• 5-chloro-2-methyl-4-isothiazolin-3-one

Topics

• Dermatitis, Contact (etiology)
• Humans
• Pharmaceutic Aids (adverse effects)
• Preservatives, Pharmaceutical (adverse effects)
• Thiazoles (adverse effects, isolation & purification, toxicity)