The glomerular tip lesion: a steroid responsive nephrotic syndrome.

Abstract

The glomerular tip nephropathy is a cause of the nephrotic syndrome and has distinct pathological features. Glomerular tufts appear normal on light microscopy except for a segmental lesion invariably present in all glomeruli at the origin of the proximal tubule. Data on twenty adults whose renal biopsies demonstrated this lesion and who were followed for a mean of 7.4 years are analyzed. Eighteen patients were treated with steroids; ten of these had complete remission of proteinuria and seven a significant reduction of their proteinuria. Ten patients had moderately impaired renal function (serum creatinine greater than 120 mumol/l) at presentation, eight received steroids and achieved a reduction in serum creatinine. The prognosis was good, with no patient developing chronic renal failure requiring dialysis.

• Authors: M Beaman, A J Howie, J Hardwicke, J Michael, D Adu
• Journal: Clinical nephrology (Clin Nephrol) Vol. 27 Issue 5 Pg. 217-21 (May 1987) ISSN: 0301-0430 [Print] Germany
• PMID: 3594937 (Publication Type: Journal Article)

Chemical References

• Cyclophosphamide
• Prednisolone
• Azathioprine

Topics

• Adult
• Azathioprine (therapeutic use)
• Cyclophosphamide (therapeutic use)
• Drug Therapy, Combination
• Follow-Up Studies
• Glomerulonephritis (drug therapy, pathology)
• Humans
• Kidney Glomerulus (pathology)
• Nephrotic Syndrome (drug therapy, pathology)
• Prednisolone (therapeutic use)
• Proteinuria (drug therapy, pathology)