Abstract |
Left ventricular (LV) function was investigated by left heart catheterization at rest and during exercise in 15 men 3--5 months after acute myocardial infarction. The effect of 8 mg oxyfedrine i.v. in 10 patients was compared to placebo in 5. The administration of oxyfedrine led to a significant decrease of LV end-diastolic pressure; an increase of LV dp/dt max, heart rate, LV ejection fraction and LV stroke work; and a shift of LV function curve indicating its improvement. These results give evidence for a positive inotropic effect of this drug which could have therapeutic implications in patients with impaired LV function after myocardial infarction.
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Authors | J Ressl, J Kasalický |
Journal | International journal of clinical pharmacology and biopharmacy
(Int J Clin Pharmacol Biopharm)
Vol. 16
Issue 10
Pg. 474-8
(Oct 1978)
ISSN: 0340-0026 [Print] Germany |
PMID | 359492
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Placebos
- Propiophenones
- Oxyfedrine
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Topics |
- Adult
- Aged
- Blood Pressure
(drug effects)
- Cardiac Output
(drug effects)
- Clinical Trials as Topic
- Heart
(drug effects)
- Heart Rate
(drug effects)
- Heart Ventricles
(drug effects)
- Hemodynamics
(drug effects)
- Humans
- Male
- Middle Aged
- Myocardial Contraction
(drug effects)
- Myocardial Infarction
(drug therapy)
- Oxyfedrine
(pharmacology)
- Physical Exertion
- Placebos
- Propiophenones
(pharmacology)
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