Abstract |
Cardiac electrophysiologic effects of the hydrochloride of 1-methoxymethyl-2-(1-perhydroazepinyl)ethyl ester of 2-(n)-pentyloxycarbanilic acid ( BK 129) were studied in pentobarbital anesthetized dogs. Doses of 0.5, 1 and 2 mg kg-1 i.v. produced a dose dependent slowing down of S-A and idioventricular pacemakers, increase in atrioventricular (A-V), atrial and ventricular refractoriness, and decrease in intra-atrial, A-V and intra-ventricular conduction. Retrograde ventriculoatrial conduction was affected only slightly. In dogs with A-V blockade BK 129 suppressed norepinephrine-induced acceleration of S-A and idioventricular rhythm and intra-ventricular conductivity. These results suggest that BK 129 may be an effective agent for treating cardiac arrhythmias.
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Authors | P Gibala, R Sotníková, V Knezl, J Drímal |
Journal | Arzneimittel-Forschung
(Arzneimittelforschung)
Vol. 37
Issue 3
Pg. 326-8
(Mar 1987)
ISSN: 0004-4172 [Print] Germany |
PMID | 3593445
(Publication Type: Journal Article)
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Chemical References |
- Azepines
- Carbamates
- BK 129
- Norepinephrine
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Topics |
- Anesthesia
- Animals
- Atrioventricular Node
(drug effects)
- Azepines
(pharmacology)
- Carbamates
(pharmacology)
- Dogs
- Electrophysiology
- Female
- Heart
(drug effects)
- Male
- Neural Conduction
(drug effects)
- Neuromuscular Junction
(drug effects)
- Norepinephrine
(pharmacology)
- Sinoatrial Node
(drug effects)
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