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Cardiac electrophysiologic actions of the hydrochloride of 1-methoxymethyl-2-(1-perhydroazepinyl)ethyl ester of 2-(n)-pentyloxycarbanilic acid in the anesthetized dog.

Abstract
Cardiac electrophysiologic effects of the hydrochloride of 1-methoxymethyl-2-(1-perhydroazepinyl)ethyl ester of 2-(n)-pentyloxycarbanilic acid (BK 129) were studied in pentobarbital anesthetized dogs. Doses of 0.5, 1 and 2 mg kg-1 i.v. produced a dose dependent slowing down of S-A and idioventricular pacemakers, increase in atrioventricular (A-V), atrial and ventricular refractoriness, and decrease in intra-atrial, A-V and intra-ventricular conduction. Retrograde ventriculoatrial conduction was affected only slightly. In dogs with A-V blockade BK 129 suppressed norepinephrine-induced acceleration of S-A and idioventricular rhythm and intra-ventricular conductivity. These results suggest that BK 129 may be an effective agent for treating cardiac arrhythmias.
AuthorsP Gibala, R Sotníková, V Knezl, J Drímal
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 37 Issue 3 Pg. 326-8 (Mar 1987) ISSN: 0004-4172 [Print] Germany
PMID3593445 (Publication Type: Journal Article)
Chemical References
  • Azepines
  • Carbamates
  • BK 129
  • Norepinephrine
Topics
  • Anesthesia
  • Animals
  • Atrioventricular Node (drug effects)
  • Azepines (pharmacology)
  • Carbamates (pharmacology)
  • Dogs
  • Electrophysiology
  • Female
  • Heart (drug effects)
  • Male
  • Neural Conduction (drug effects)
  • Neuromuscular Junction (drug effects)
  • Norepinephrine (pharmacology)
  • Sinoatrial Node (drug effects)

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