Relationship between the uptake and cytotoxicity of celiptium in wild type and resistant mutants of the bacterium Streptococcus pneumoniae.

Abstract

Celiptium, a cationic and amphiphilic drug currently employed in cancer chemotherapy, was found to be accumulated against its concentration gradient by the bacterium Streptococcus pneumoniae. Accumulation was reduced in Celiptium resistant amiA mutants which were also observed to have reduced electric transmembrane potentials delta psi. This suggested a relationship between Celiptium toxicity and accumulation in S. pneumoniae, and indicated a delta psi - driven uptake in a manner reminiscent of that observed for other lipophilic cations such as tetraphenylphosphonium.

• Authors: A M Sautereau, J F Tocanne, M C Trombe
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 145 Issue 2 Pg. 927-33 (Jun 15 1987) ISSN: 0006-291X [Print] United States
• PMID: 3593380 (Publication Type: Journal Article)

Chemical References

• Alkaloids
• Ellipticines
• Onium Compounds
• Organophosphorus Compounds
• elliptinium
• tetraphenylphosphonium
• Methotrexate

Topics

• Alkaloids (metabolism)
• Drug Resistance, Microbial
• Ellipticines (metabolism)
• Membrane Potentials
• Methotrexate (metabolism)
• Mutation
• Onium Compounds (metabolism)
• Organophosphorus Compounds (metabolism)
• Streptococcus pneumoniae (genetics, metabolism)
• Temperature