Seroprevalence of anti-myelin oligodendrocyte glycoprotein antibodies in adults with myelitis.

Abstract

Although myelitis is the second most common presentation in adults with myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD), studies on MOG-IgG seroprevalence in patients with myelitis episodes are sparse. Herein, we investigated MOG-IgG seroprevalence in Korean adults who exhibited myelitis since 2017. Among 151 adults with acute myelitis, 11 (7.3%) tested positive for MOG-IgG by the initial screening and 10 (6.6%) patients were finally diagnosed with MOGAD during the study period. This study is the first to provide data on MOG-IgG seroprevalence in adults with myelitis and supports the clinical utility and importance of MOG-IgG testing in myelitis episodes.

• Authors: Ki Hoon Kim, Su-Hyun Kim, Jae-Won Hyun, Yeseul Kim, Hyewon Park, Ho Jin Kim
• Journal: Annals of clinical and translational neurology (Ann Clin Transl Neurol) Vol. 9 Issue 9 Pg. 1481-1486 (09 2022) ISSN: 2328-9503 [Electronic] United States
• PMID: 35932473 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

Chemical References

• Immunoglobulin G
• Myelin-Oligodendrocyte Glycoprotein

Topics

• Humans
• Immunoglobulin G
• Myelin-Oligodendrocyte Glycoprotein
• Myelitis (epidemiology)
• Oligodendroglia
• Seroepidemiologic Studies