Effects of indeloxazine hydrochloride (YM-08054) on anoxia.

Abstract

Effects of indeloxazine hydrochloride [(+/-)-2-[(inden-7-yloxy)methyl]morpholine hydrochloride, YM-08054] on anoxia were examined. Indeloxazine significantly prolonged survival time of mice subjected to anoxia and improved anoxia-induced impairment of the passive and active avoidance learnings in rats. Indeloxazine at doses inducing anti-anoxic actions showed no effect on cerebral blood flow in cats and pentobarbital sleeping time in mice. Therefore, anti-anoxic actions of indeloxazine are not attributable to cerebral vasodilative or central depressant activities. Calcium hopantenate (cerebral metabolic enhancer) also showed anti-anoxic actions, whereas neither viloxazine, amitriptyline (antidepressant) nor dihydroergotoxine (cerebral vasodilator) showed any effect on anoxia. These results suggest that indeloxazine possesses anti-anoxic activities similar to calcium hopantenate. The mode of anti-anoxic actions of indeloxazine is also discussed.

• Authors: M Yamamoto, M Shimizu
• Journal: Archives internationales de pharmacodynamie et de therapie (Arch Int Pharmacodyn Ther) Vol. 286 Issue 2 Pg. 272-81 (Apr 1987) ISSN: 0003-9780 [Print] Belgium
• PMID: 3592867 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Morpholines
• Piperazines
• Dihydroergotoxine
• Amitriptyline
• pantogab
• Pantothenic Acid
• gamma-Aminobutyric Acid
• Viloxazine
• cinepazide
• indeloxazine

Topics

• Amitriptyline (therapeutic use)
• Animals
• Avoidance Learning (drug effects)
• Cerebrovascular Circulation (drug effects)
• Dihydroergotoxine (therapeutic use)
• Female
• Hypoxia (mortality, prevention & control, psychology)
• Male
• Mice
• Mice, Inbred ICR
• Morpholines (therapeutic use)
• Pantothenic Acid (analogs & derivatives, therapeutic use)
• Piperazines (therapeutic use)
• Rats
• Rats, Inbred Strains
• Sleep (drug effects)
• Time Factors
• Viloxazine (therapeutic use)
• gamma-Aminobutyric Acid (analogs & derivatives, therapeutic use)