[Cyclosporin therapy in minimal change nephritis].

Abstract

In 5 cases with minimal change nephritis Cyclosporine A has been added to the conventional steroid therapy, when relapse of nephrotic syndrome occurred while reducing the daily prednisolone dose. The intended cyclosporine trough level ranged from 250 ng/ml to 450 ng/ml whole blood, estimated by the RIA method. Proteinuria disappeared in 4 out of the 5 cases, in the other one urinary protein excretion was strikingly reduced. In the 4 cases with complete remission of proteinuria prednisolone was tapered. These patients have cyclosporine A as the sole immunosuppressive drug since 56 weeks and do not show proteinuria. Side effects of cyclosporine therapy have been slight deterioration of kidney function in 2 out of the 5 cases and the occurrence of hypertension in 4 patients.

• Authors: P Balcke, K Derfler, F Stockenhuber, H Kopsa, G Sunder-Plassmann
• Journal: Wiener klinische Wochenschrift (Wien Klin Wochenschr) Vol. 99 Issue 7 Pg. 242-5 (Apr 03 1987) ISSN: 0043-5325 [Print] Austria
• Vernacular Title: Cyclosporintherapie bei Minimal-change-Nephritis.
• PMID: 3590804 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cyclosporins
• Prednisolone

Topics

• Adult
• Cyclosporins (therapeutic use)
• Drug Therapy, Combination
• Female
• Humans
• Kidney Function Tests
• Male
• Middle Aged
• Nephrosis, Lipoid (drug therapy)
• Prednisolone (therapeutic use)