[Lectin receptors in transitional cell tumors of the bladder].

Abstract

Binding sites for lectins of peanuts, soya-beans and concanavalin A were identified in the tissues of normal human urinary bladder and its transitional cell tumors (31 patients) using the lectin-peroxidase technique. No binding sites for any of the lectins were found in normal urothelium. Receptors for peanut and soya-bean lectins were observed on the plasma membranes of 20% of tumor cells in transitional cell papillomas. A diffuse distribution of those lectins in tumor cell cytoplasm was interpreted as a tendency to malignant transformation of tumor. There were no concanavalin A receptors in tumor cells.

• Authors: I M Dmitruk, D D Zerbino, A D Lutsik
• Journal: Voprosy onkologii (Vopr Onkol) Vol. 33 Issue 4 Pg. 60-5 ( 1987) ISSN: 0507-3758 [Print] Russia (Federation)
• Vernacular Title: Retseptory nekotorykh lektinov v perekhodno-kletochnykh opukholiakh mochevogo puzyria.
• PMID: 3590660 (Publication Type: English Abstract, Journal Article)

Chemical References

• Lectins
• Peanut Agglutinin
• Plant Lectins
• Receptors, Mitogen
• Soybean Proteins
• soybean lectin
• Concanavalin A
• Acetylgalactosamine
• Mannose
• Galactose

Topics

• Acetylgalactosamine (analysis)
• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Transitional Cell (analysis, pathology)
• Concanavalin A (analysis)
• Galactose (analysis)
• Histocytochemistry
• Humans
• Lectins (analysis)
• Male
• Mannose (analysis)
• Middle Aged
• Papilloma (analysis, pathology)
• Peanut Agglutinin
• Plant Lectins
• Receptors, Mitogen (analysis)
• Soybean Proteins
• Urinary Bladder (analysis, pathology)
• Urinary Bladder Neoplasms (analysis, pathology)