Phase II study of S-1 plus cisplatin with concurrent radiotherapy for locally advanced thymic carcinoma: Results of the LOGIK1605/JART-1501 study.

Abstract

BACKGROUND:

Combination chemotherapy is used to treat advanced thymic carcinoma; however, the effects are insufficient.

METHODS:

Previously untreated patients with unresectable locally advanced thymic carcinoma received two cycles of 80 mg/m2 /day S-1 orally on days 1-14 plus 60 mg/m2 /day cisplatin intravenously on day 1, and concurrent radiotherapy (60 Gy).

RESULTS:

Three patients were enrolled into the study. Toxicity and survival were assessable in all patients, but the treatment response was only assessable in one patient. The study was terminated because of poor case recruitment. The patients' characteristics were as follows: male/female = 2/1; PS 0/1 = 2/1; median age (range) = 59 (55-72); and stage III/IV = 2/1. The patient in which the treatment response was assessed exhibited SD (response rate: 0%). In both nonevaluable cases, the second course of chemotherapy was judged to be post-protocol treatment because it was delayed by ≥14 days, but a CR and PR were achieved after the end of the study, respectively. G4 leukopenia/neutropenia and G3 febrile neutropenia occurred in one patient each (33%). The median time to tumor progression was 17.6 months, and the 1-, 2-, 3-, and 4-year survival rates were 67, 33, 33, and 33%, respectively. The median overall survival time was not reached, and the 1-, 2-, 3-, and 4-year survival rates were 100, 67, 67, and 67%, respectively.

CONCLUSIONS:

Although it was difficult to recruit patients, there was a long-term survivor >4 years who appeared to have achieved a CR, indicating that such chemoradiotherapy may be effective against locally advanced thymic carcinoma.

• Authors: Minoru Fukuda, Masafumi Yamaguchi, Takuya Yamazaki, Soichiro Funaki, Hiroshi Mukae, Junya Fukuoka, Kazuki Nabeshima, Hisashi Tateyama, Kazuto Ashizawa, Noriyuki Tomiyama, Masaki Hara, Takashi Seto, Meinoshin Okumura, Kenji Sugio
• Journal: Thoracic cancer (Thorac Cancer) Vol. 13 Issue 17 Pg. 2499-2506 (09 2022) ISSN: 1759-7714 [Electronic] Singapore
• PMID: 35869676 (Publication Type: Clinical Trial, Phase II, Journal Article)
• Copyright: © 2022 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.

Chemical References

• Drug Combinations
• S-1 plus cisplatin
• Cisplatin

Topics

• Aged
• Chemoradiotherapy (methods)
• Cisplatin
• Combined Modality Therapy
• Drug Combinations
• Female
• Humans
• Male
• Middle Aged
• Neoplasm Staging
• Neutropenia
• Thymoma (drug therapy, pathology, radiotherapy)
• Thymus Neoplasms (drug therapy, pathology, radiotherapy)