Reticular epithelial edema after penetrating keratoplasty in a patient taking netarsudil.

Abstract

Netarsudil is a relatively new medication for the treatment of primary open-angle glaucoma and ocular hypertension. It has been associated with red eyes and burning after instillation. Reticular epitheliopathy is a relatively rare complication of netarsudil that has been described in patients with preexisting corneal edema. We report the case of a healthy 76-year-old woman who developed reticular epitheliopathy after full-thickness penetrating keratoplasty that completely resolved following discontinuation of the medication. In cases where netarsudil is initiated for treatment of glaucoma or, off-label, endothelial dysfunction, reticular epithelial edema should be considered in patients complaining of a decline in vision and severe pain.

• Authors: Lauren J Jeang, Ankit S Shah, Jon D Hammer, Sonal S Tuli
• Journal: Digital journal of ophthalmology : DJO (Digit J Ophthalmol) Vol. 28 Issue 8 Pg. 34-37 ( 2022) ISSN: 1542-8958 [Electronic] United States
• PMID: 35854963 (Publication Type: Case Reports)
• Copyright: Copyright ©2022. All rights reserved. Reproduction in whole or in part in any form or medium without expressed written permission of the Digital Journal of Ophthalmology is prohibited.

Chemical References

• Benzoates
• beta-Alanine
• netarsudil

Topics

• Aged
• Benzoates
• Edema (complications)
• Female
• Glaucoma (etiology)
• Glaucoma, Open-Angle (complications, drug therapy, surgery)
• Humans
• Intraocular Pressure
• Keratoplasty, Penetrating (adverse effects)
• beta-Alanine (analogs & derivatives)