Targeted Anti-Hepatocellular Carcinoma Research of Targeted Peptides Combined with Drug-Loaded Cell-Derived Microparticles.

Abstract

To conduct an anti-tumor research by using targeted drug-loaded cell-derived microparticles to target the tumor microenvironment and enhance NK cell killing function. In this experiment, we obtained HepG2 tumor cell-derived microparticles by physical extrusion, high speed centrifugation and filtration, modified the hepatocellular carcinoma targeting peptide SP94 on the surface of microparticles and encapsulated the TGF-β inhibitor SB505124. Finally we validated and analyzed whether the new drug delivery system can target to tumor site and enhance the anti-tumor function of NK cells. This type of novel targeted cell-derived microparticles drug delivery system will provide a novel idea for tumor immunotherapy.

• Authors: Xu Ximei, Luo Yiqun, Zhang Zhikun, Nie Yueli, Liu Xiuli, Shi Wei, Wu Tao, Wu Pan, Liu Xiyu, Huang Yong, Zhao Yongxiang, Gan Lu, Zhong Liping, Chen Qiaoying, He Jian
• Journal: Journal of biomedical nanotechnology (J Biomed Nanotechnol) Vol. 18 Issue 4 Pg. 1009-1018 (Apr 01 2022) ISSN: 1550-7033 [Print] United States
• PMID: 35854442 (Publication Type: Journal Article)

Chemical References

• Peptides
• Pharmaceutical Preparations

Topics

• Carcinoma, Hepatocellular (drug therapy)
• Cell Line, Tumor
• Cell-Derived Microparticles (metabolism, pathology)
• Hep G2 Cells
• Humans
• Liver Neoplasms (drug therapy, metabolism)
• Peptides
• Pharmaceutical Preparations
• Tumor Microenvironment