Abstract | BACKGROUND: METHODS: This parallel-group, single-blind randomized control trial at a tertiary care medical center in South Korea was conducted to determine the difference in the quality of recovery between the patients administered remimazolam and those administered an inhalant anesthetic agent. A total of 168 patients aged 19-65 years who underwent elective laparoscopic cholecystectomy or robotic gynecologic surgery were considered for enrollment. Randomization was performed using sealed envelopes containing computer-generated random allocation sequences. Remimazolam was administered for the maintenance of anesthesia in the remimazolam group (Group R), and desflurane was administered in the desflurane group (Group D). The induction protocol and the target value of the bispectral index were identical in both groups. Patients were blinded to the drug that was administered until they finished the postoperative questionnaire. The main outcome measure was the decrement of the QoR-40 score on postoperative day 1 compared to the QoR-40 score on the day before surgery. RESULTS: A total of 165 patients were analyzed. The preoperative and postoperative global QoR-40 scores were 183 and 152 (IQR 173-192 and 136-169), respectively. The perioperative decrement of the global QoR-40 score was 29.96 ± 22.49. The decrement of the QoR-40 score was smaller in Group R than in Group D (26.99 versus 32.90, respectively; mean difference 5.91, 95% confidence interval -0.96-12.79). After adjustment for sex, the type of surgery and surgical time, the administration of remimazolam resulted in a 7.03-point (95% CI 0.35-13.72) less decrement of the QoR-40 score than desflurane. There were no severe adverse events in either group. CONCLUSION: TRIAL REGISTRATION: KCT0006288 , Clinical Research Information Service (CRIS), Republic of Korea Registration date: 23/06/2021.
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Authors | Seung Woo Song, Yo Nam Jang, Min-Woo Yoon, Yeong-Gwan Jeon |
Journal | BMC anesthesiology
(BMC Anesthesiol)
Vol. 22
Issue 1
Pg. 226
(07 16 2022)
ISSN: 1471-2253 [Electronic] England |
PMID | 35842575
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2022. The Author(s). |
Chemical References |
- Benzodiazepines
- remimazolam
- Desflurane
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Topics |
- Anesthesia, General
(methods)
- Benzodiazepines
- Desflurane
- Female
- Humans
- Postoperative Nausea and Vomiting
- Single-Blind Method
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